Which reactions need temperature control in the process of chemical and pharmaceutical production?

Precise temperature control plays a crucial role in the reaction process during synthesis/crystallization in the production of chemical and pharmaceutical products. In the field of fine chemicals, many chemical reaction processes and crystallization processes are carried out in a low temperature environment. When the reaction is carried out in a low temperature environment, the amount of impurities produced is obviously reduced, and the purity of the product is increased, so that the reacted product has a high selectivity. Compared with the traditional process technology, a reasonable selection of the working temperature range can improve product quality and synthesis quality, improve production efficiency and reduce production costs. The premise of realizing all this is the control of the dynamic temperature in the reaction process. In the crystallization process of pure product, in order to obtain higher product quality, it is necessary to strictly follow the specified cooling rate.

Decarboxylation is a chemical reaction that removes a carboxyl group and releases carbon dioxide (CO2) and replaces it with hydrogen atoms. The term refers to the states of reactants and products. Decarboxylation is one of the oldest known organic reactions because it usually requires simple pyrolysis and distillation of volatile products from the reactor. Heating is required because the reaction is less favorable at low temperatures. Yield is highly sensitive to conditions. For example, the temperature required for the polar activated decarboxylation reaction method is as high as 140 °C.

Winterization is one of the methods of crystallization separation. It is to stir the oil slowly, control the cooling speed, and cool it to about 4~6 ℃. The solid fat is formed into larger crystals and separated out. Winterized oil is characterized by passing the freezing test, that is, it is not cloudy after 5.5 hours at 0 °C. Another example is that the whole process of enzyme extraction is kept at low temperature because enzymes are proteins. Proteins are denatured at high temperatures, thereby losing their activity. The temperature is too low, which is not conducive to the extraction operation. So careful temperature management in the processing plant not only ensures high extraction rates, but also efficient recovery of the solvent used. It is conceivable that temperature control plays a decisive role in the extraction process.

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